Inorganic Theranostic Agents as the Tumor Microenvironment-Mediated Nanoplatform for Tumour-Specific Therapy

Wenbo Bu *

 

Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, P. R. China.

 

* Corresponding author. E-mail: wbbu@chem.ecnu.edu.cn

 

Presented: 2018 Chinese Conference on Oncology. Shenyang, China, Aug. 17-19, 2018; Published: Oct. 17, 2018

 

Citation: Wenbo Bu, Inorganic Theranostic Agents as the Tumor Microenvironment-Mediated Nanoplatform for Tumour-Specific Therapy. Nano Biomed. Eng., 2018, Special Issue: 308.

 

Abstract

In this talk, I will focus on the latest progresses of our group on a variety of inorganic theranostic agents as the tumor microenvironment-mediated nanoplatform for the tumour-specific therapy. First, I will offer a thorough description of chemodynamic therapy (CDT), which is defined as the disproportionation of hydrogen peroxide (H₂O₂) through an intratumoral Fenton reaction. Such an endogenous chemical energy to generate cytotoxic·OH could substantially surmount the limitations of penetration and nonspecificity. Then, I will introduce the specific cancer-starving therapy. We provides a compelling proof-of-concept for the use of PVP-modified Mg₂Si nanoparticles as potential candidates for use as a tumor-targeted deoxygenating agent. This cancer-starvation therapy avoids the poisoning of normal/cancer cells by toxic drugs, and largely reduces the toxic side effects to normal cells and tissues, featuring high therapeutic biosafety.

 

Keywords: Microenvironment-mediated theranostic agents; Chemodynamic therapy; Cancer-starvation therapy

 

Copyright© Wenbo Bu. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

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