Synthesis, Characterization, Spectroscopic and Biological Studies of Zn(II), Mn(II) and Fe(II) Theophylline Complexes in Nanoscale

Ahmad Hussein Ismail, Hassanain Kamil Al-Bairmani, Zainab Sabri Abbas, Ahmed Mahdi Rheima


Three nanocomplexes of Zn(II), Mn(II), Fe(II) with theophylline were synthesized by ultrasonic sonication method. Melting point, molar conductivity, solubility, flame atomic absorption, Fourier-transform infrared spectroscopy (FTIR), ultraviolet–visible (UV–vis) spectroscopy and C/H/N/S elemental analyses were used to investigate and suggest the structure of the nanocomplexes. Size and morphology of the nanocomplexes were measurement by transmission electron microscopy (TEM), ranging from 6 - 22 nm. Efficacy of the nanocomplexes synthesized was examined against four types of bacterial strains: Staphylococcus aureus, Bacillus subtilis (Gram-positive bacteria), Klebsiella pneumonia and Escherichia coli (Gram-negative bacteria). The results showed that all nanocomplexes had very high susceptibility to inhibit bacterial growth, as indicated by their inhibition zones between 98% and 100%.

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Nano Biomedicine and Engineering.

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